Screening newborns for hemoglobinopathies--enduring challenge
نویسندگان
چکیده
منابع مشابه
Automated HPLC screening of newborns for sickle cell anemia and other hemoglobinopathies.
Automated HPLC is used to test dried blood-spot specimens from newborns for hemoglobins (Hb) F, A, S, C, E, and D. We present the method and report on its performance determined during >4 years of testing 2.5 x 10(6) newborns. The method features automated derivation of presumptive phenotypes; quantitative quality control and proficiency testing; throughput of one specimen per minute; small sam...
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BACKGROUND Newborn screening (NBS) for hemoglobinopathies facilitates early identification of affected individuals to ensure the prompt institution of comprehensive medical care for affected newborns in California. When linked to extensive follow-up and education, NBS has been shown to significantly reduce mortality in children with sickle cell disease. Due to changing immigration patterns from...
متن کاملScreening for hemoglobinopathies in neonates in Argentina.
nificant lengthening of PFS was the result of IFN maintenance therapy, as already reported.10 Our experience, although limited, confirms the efficacy of purine analogs as second line therapy. In agreement with Rai et al.8 the very high projected survival probability of our series can be explained mainly by a two step therapeutic strategy made up of IFN first line therapy and purine analog salva...
متن کاملNewborn screening for non-sickling hemoglobinopathies.
The hemoglobinopathies encompass a heterogeneous group of disorders associated with mutations in both the alpha-globin and beta-globin genes. Non-sickling disorders are found primarily in individuals of Mediterranean, Asian and Southeast Asian ancestry. With rapid growth in the Asian and Hispanic segments of the US population, the geographic distribution of hemoglobinopathies is expected to bec...
متن کاملPrenatal and newborn screening for hemoglobinopathies.
The hemoglobinopathies encompass a heterogeneous group of disorders associated with mutations in both the alpha-globin and beta-globin genes. Increased immigration of high-risk populations has prompted the implementation of prenatal and newborn screening programs for hemoglobinopathies across Europe and North America. In Canada, the UK, and other European countries, prenatal screening to identi...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1996
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/42.5.658